B16F0 melanoma exosomes deliver a unique and complex biological payload that includes Ptpn11 to suppress T lymphocyte function
نویسندگان
چکیده
Background Host immunity is coordinated through a complex network of intercellular communication. Similar to the sculpting of tumor antigens during oncogenesis, a related hypothesis is that proteins secreted by malignant cells are shaped by somatic evolution. Malignant cells that then emerge secrete proteins that alter intercellular communication to promote tumor growth. As exosomes represent an emerging mode of cell-to-cell communication through the delivery of proteins and coding and non-coding RNAs, the objective of this study was to test this hypothesis by characterizing the impact of exosomes derived from three melanocyte cell lines on T cell function, with an emphasis on exosomal mRNA.
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